In a new Science study, researchers report that specific regions dense in cytosine and guanosine dinucleotides are epigenetically modified during inflammation to enable gene expression and that these changes persist during the animal’s lifetime.

The finding has implications for understanding how the genome determines the longevity of memory, which affects tissue fitness.

Learn more in a new Science Perspective.

Specific DNA sequence features encode the persistence of epigenetic memory of inflammation.

Guillaume Blot and Przemyslaw Sapieha Authors Info & Affiliations

Science

Vol 391, Issue 6792