While diet and inflammation likely contribute, the underlying molecular mechanism has been unclear.
https://doi.org/10.1172/JCI196238 Here, Junichi Sadoshima & team find direct stimulation of IL-6 transcription by PPARα in cardiomyocytes plays an important role in mediating the initial development of obesity cardiomyopathy.
The figure indicates binding of PPARα to NFkB (via PLA assay).
1Rutgers New Jersey Medical School Department of Cell Biology and Molecular Medicine, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
2Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Address correspondence to: Junichi Sadoshima, Cardiovascular Research Institute, Rutgers Biomedical and Health Science, 185 South Orange Ave., MSB G609, Newark, New Jersey, 7,103, USA. Phone 973.972.8619; Email: [email protected].