https://doi.org/10.1172/jci.insight.
Here, Tobias B. Huber & team use a state-of-the-art, tour de force experimental design to show LSD1 regulates kidney development, and its dysfunction disrupts key kidney cells, leading to cyst formation in mouse and organoid models.
The image shows severe structural changes in the adult mouse kidney with loss of KDM1a. Nephrology.
4Faculty of Biology, Albert Ludwigs University of Freiburg, Freiburg, Germany.
5Institute of Medical Bioinformatics and Systems Medicine and.
6Institute of Surgical Pathology, Faculty of Medicine, Medical Center — University of Freiburg, Freiburg, Germany.