Inflammatory gene transcription regulation.

While we recognize that inflammatory responses are essential for immunity to microbial infections, it is evident from clinical proof that these responses must be properly controlled to prevent potential detrimental consequences.

Over the past decades, multiple immunosuppressive mechanisms have been identified at distinct levels, including mechanisms that target immune receptor complexes and regulate signal transduction.

However, the molecular mechanisms by which inflammatory gene transcription is precisely finetuned remain poorly defined.

Here, the author highlight that a comprehensive understanding of how the ubiquitination–deubiquitination process directly controls the transcription of inflammatory genes may reveal novel avenues for therapeutic intervention.

Finally, the review provides insight into the importance of understanding the spatiotemporal regulation of inflammatory gene transcription at the gene specific level. sciencenewshighlights ScienceMission https://sciencemission.com/inflammatory-gene-transcription

Transcriptional responses are initiated immediately after the recognition of pathogen-associated molecular patterns by pattern recognition receptors, enabling host cells to deal with inflammatory stimuli, including microbial infections. In turn, these inflammatory transcriptional programs must be tightly controlled to prevent potential detrimental consequences, such as immunopathological or even fatal outcomes. To date, many well-defined mechanisms have been reported that contribute to the transcriptional control of inflammatory gene expression at multiple levels. Here, I mainly focus on reviewing recent progress in post-translational modifications, in particular, how the ubiquitination–deubiquitination cycle controls inflammatory gene transcription mediated by nuclear factor kappa-light-chain-enhancer of activated B cells and interferon signaling pathways.