Do we need better ways to detect clonal hematopoiesis of indeterminate potential (CHIP)?
In this Research Letter, Alexander G. Bick & team find epidemiology studies underestimate the strength of the association between clonal hematopoiesis and disease due to false negatives from shallow, whole-genome versus deep targeted sequencing.
Address correspondence to: Alexander Bick, 2,200 Pierce Ave., 550 RRB, Nashville, Tennessee, 37,232, USA. Email: [email protected].
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1Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.