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Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke

New study from Weijie Chen, Xin Wang, Tingting Huang, Weifeng Yu.

Florent Ginhoux, Peiying Li (Shanghai Jiao Tong University) and colleagues identifies hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived macrophages in the ischemic brain after stroke through mediating phosphatidylcholine synthesis.


This study identifies hypoxia-inducible protein 2 (HIG2) as a key regulator of anti-inflammatory property of Ly6ChighLy6Glow monocyte-derived macrophages i.

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