Here, Sarah Gaffen & team report on the noncanonical RNA binding protein Arid5a as an activator of TNF signaling that is elevated in human RA tissues. And in mice… its loss results in resistance to collagen-induced arthritis:
The figure shows TNF stimulation causes Arid5a accumulation in the cytoplasm in a murine stromal fibroblast cell line untreated (left) and treated (right); Arid5a (red); RPL7A (green); nuclei (blue).
1Division of Rheumatology & Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
2BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic.
3School of Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.