Arteries become clogged. Blood flow is restricted and oxygen is cut off. The result is a heart attack, the world’s leading cause of death.

The conventional approach to studying and treating these episodes is to focus on the heart as an isolated organ. University of California San Diego research, led by the School of Biological Sciences, is upending the way heart attacks are viewed under a transformative new understanding of how cardiac events are interconnected with other systems.

In a study published in the journal Cell, Postdoctoral Scholar Saurabh Yadav, Assistant Professor Vineet Augustine and their colleagues describe a comprehensive new picture of heart attacks and their resulting damage by connecting the heart, the brain and the nervous and immune systems.