Sequential childhood or early adulthood screening for familial hypercholesterolemia may lower lifetime CVD risk, but is unlikely to be cost-effective unless ongoing follow-up for elevated cholesterol is widely implemented.

This study uses a computer model to estimate the cost-effectiveness of sequential familial hypercholesterolemia screening at age 10 or 18 years using 3 low-density lipoprotein cholesterol (LDL-C) thresholds.