New organoid research published in Stem Cell Reports:

Cell press | gairdner foundation | sickkids foundation | california institute for regenerative medicine | uni bayreuth.

Walther and colleagues employed an automated live-cell single-molecule tracking pipeline to study the diffusive behavior of the transcription factor SOX9 during adult differentiation and fetal-like reprogrammed states in intestinal organoid models. The authors linked distinct fractions of chromatin-bound SOX9 molecules to specific cellular states in enteroid monolayers, thereby paving the way to unravel molecular mechanisms underlying differentiation and organoid phenotypes.