Researchers from the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), and NHG Health’s Institute of Mental Health (IMH) have mapped how brain networks differ in individuals at Clinical High Risk (CHR) for psychosis, providing a new perspective on the mechanisms underlying the disease onset.

Published in Molecular Psychiatry, the study utilized advanced neuroimaging methods to identify early, network-level changes in more than 3,000 individuals at varying levels of risk.

The study—led by Dr. Siwei Liu, Senior Research Scientist, and Associate Professor Juan Helen Zhou, Director, both at the Center for Translational Magnetic Resonance Research (TMR), NUS Medicine, and in collaboration with Associate Professor Jimmy Lee, Senior Consultant Psychiatrist and Clinician-Scientist at IMH—sought to determine how brain networks can reveal signs in young individuals with heightened clinical risk of developing psychosis.