A new study led by University of California, Irvine’s Center for the Neurobiology of Learning and Memory researchers found that aging changes the brain’s overall shape in measurable ways. Instead of focusing only on the size of specific regions, the team used a new analytic method to see how the brain’s form shifts and distorts over time.

The analysis revealed substantial alterations in brain shape, which were closely associated with declines in memory, reasoning and other cognitive functions. This suggests that the shape of the brain can serve as a reliable indicator of its overall health. The study appears in Nature Communications.

“Most studies of brain aging focus on how much tissue is lost in different regions,” said Niels Janssen, Ph.D., senior author and professor at Universidad de La Laguna in Spain and visiting faculty at the CNLM. “What we found is that the overall shape of the brain shifts in systematic ways, and those shifts are closely tied to whether someone shows cognitive impairment.”