Carboxylic acids are common components in bioactive compounds and serve as widely available building blocks in organic synthesis. When transformed into carboxy radicals, these acids can initiate the formation of valuable carbon-carbon and carbon-heteroatom bonds, a key step in the creation of new materials and pharmaceutical agents. Despite their utility, few existing methods rely on cost-effective catalysts.

Addressing this gap, a team from WPI-ICReDD and the University of Shizuoka developed a straightforward hydrogen atom transfer (HAT) strategy that selectively converts carboxylic acids into carboxy radicals. This method employs xanthone, a commercially available and inexpensive organic ketone, as the photocatalyst. The study was recently published in the Journal of the American Chemical Society.