Microplastic pollution is a severe ecological and environmental issue and is also one of the important risk factors affecting human health. Polylactic acid (PLA), a medical biodegradable material approved by the FDA, is an important material to replace petroleum-based plastics.

Although PLA has achieved large-scale application in food packaging, its brittle characteristics make it more likely to generate microplastic particles. These particles can efficiently invade the gut through the food chain and trigger unknown biotransformation processes at the microbiota–host interface. Therefore, elucidating precisely the transformation map of PLA microplastics within the living body is crucial for assessing their safety.

In a study published in the Proceedings of the National Academy of Sciences, a research team led by Prof. Chen Chunying from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences has revealed the complete biological fate of PLA microplastics (PLA-MPs) in the gut of mice, particularly focusing on their microbial fermentation into endogenous metabolites and their involvement in the carbon cycle.