Traditional microscopy often relies on labeling samples with dyes, but this process is costly and time-consuming. To overcome these limitations, researchers have developed a computational quantitative phase imaging (QPI) method using chromatic aberration and generative AI.

By leveraging the natural variations in focus distances of different wavelengths, the technique constructs through-focus image stacks from a single exposure. With the help of a specially trained diffusion model, this approach enables high-quality imaging of biological specimens, including real-world clinical samples like red blood cells. The breakthrough could revolutionize diagnostics, providing an accessible and efficient alternative to conventional imaging techniques.

Revealing Insights Without Labels