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Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair

Applying tissue maturation techniques to engineered cartilage grafts produces more functionally faithful grafts and leads to superior clinical outcomes in patients with knee cartilage injuries, shows a new multicenter clinical trial.

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Engineered hyaline-like cartilage tissues are superior to immature cell-based grafts for the therapy of cartilage defects in the human knee.

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