Longevity snapshot 7 — cellular rejuvenation protects neurons.

Reviewing a Canadian study which uses cellular rejuvenation to protect retinal neurons in a mouse model of multiple sclerosis, preserving the vision of the mice.

Study reviewed:

In this manuscript, Drake et al. describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) like that of cortical neurons in patients with multiple sclerosis. Partial reprogramming with AAV2-Oct4-Sox2-Kl4 to rejuvenate the transcriptome results in improved RGC survival and visual acuity during EAE.