Immunotactoid glomerulopathy occurs in adults, on average at 60 years of age, and often presents with nephrotic proteinuria, reduced glomerular filtration rate, and hypocomplementemia in half of affected patients. Patients do not have cryoglobulins, but a circulating monoclonal paraprotein and/or lymphoplasmacytic malignancy is present in about two-thirds. Prognosis depends on the outcome of the associated disease, with half of the affected patients achieving remission with therapy directed at the malignancy.