Summary: Researchers have mapped over 70,000 synaptic connections in rat neurons using a silicon chip with 4,096 microhole electrodes, significantly advancing neuronal recording technology. Unlike traditional electron microscopy, which only visualizes synapses, this method also measures connection strength, providing deeper insight into brain network function.

The chip mimics patch-clamp electrodes but at a massive scale, enabling highly sensitive intracellular recordings from thousands of neurons simultaneously. Compared to their previous nanoneedle design, this new approach captured 200 times more synaptic connections, revealing detailed characteristics of each link.

The technology could revolutionize neural mapping, offering a powerful tool for studying brain function and diseases. Researchers are now working to apply this system in live brains to further understand real-time neural communication.