Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time.

Now, a team of Broad and Calico scientists has developed PERISCOPE, an approach that brings the power of microscopy imaging to genome-scale CRISPR screens in a scalable way. The new technique lets researchers study the effects of perturbing over 20,000 genes on hundreds of image-based cellular features.

Broad.io/PERISCOPE

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PERISCOPE, a technique for genome-wide imaging screens, is helping Broad scientists understand the connections between genes and traits.