NUS researchers found that deuterated water (D₂O) reduces pain by modulating the TRPV1 ion channel, offering a non-addictive alternative to conventional painkillers.
Researchers from the National University of Singapore (NUS), in partnership with Peking University, China, have uncovered new insights into the TRPV1 (transient receptor potential vanilloid 1) ion channel and its role in pain perception. Their findings demonstrate how solvent molecules can influence pain signals, paving the way for potential development of safer, non-addictive pain management strategies.
Effective pain management is vital for improving quality of life and overall well-being. The TRPV1 ion channel, which plays a key role in detecting pain, expands its pore when activated, enabling ions and larger molecules to pass through. However, the ability of water molecules to permeate the TRPV1 channel has remained uncertain.
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