Dec 30, 2023

Brain Inflammation May Underlie Neuropsychiatric Symptoms of Dementia

Posted by in category: neuroscience

I’m thinking my autistic sister has this. Maybe my 80 year old mother too. Short but informative article.

Neuroinflammation—as measured by levels of activated microglia, the brain’s immune cells—was strongly linked with irritability, agitation, and nighttime disturbances in people with dementia, recent research found. The results, published in JAMA Network Open, were based on data from a cross-sectional study that involved 109 participants aged 38 to 87 years, about two-thirds of whom did not have cognitive impairment.

Higher levels of microglial activation, and particularly microglial activation–associated irritability, in participants with dementia were also tied to greater distress in their caregivers, family members, or close friends.

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