Sep 24, 2023

The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy

Posted by in category: biotech/medical

A recent Science Immunology Review suggests combining inhibitory strategies, such as ICI, alongside radiotherapy may counteract the creation of immunosuppressive adenosine during Cancer immunotherapy.

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Adenosine generation is a rheostat of DNA damage-induced immune signaling in the tumor microenvironment.

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