A team of scientists led by Masaya Hagiwara of RIKEN national science institute in Japan has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques. The group also recently demonstrated the ability to use the device to build organoids that faithfully reproduce the asymmetric genetic expression that characterizes the actual development of organisms. The device has the potential to revolutionize the way we test drugs, and could also provide insights into how tissues develop and lead to better techniques for growing artificial organs.
Scientists have long struggled to create organoids—organ-like tissues grown in the laboratory—to replicate actual biological development. Creating organoids that function similarly to real tissues is vital for developing medicines since it is necessary to understand how drugs move through various tissues. Organoids also help us gain insights into the process of development itself and are a stepping stone on the way to growing whole organs that can help patients.
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