Brain tissue is one of the most intricate tissue specimens that scientists have arguably ever dealt with. Packed with an immeasurable amount of information, the human brain is the most sophisticated computational device with its network of around 86 billion neurons.
Understanding such complexity is a difficult task, and therefore making progress requires technologies to unravel the tiny, complex interactions taking place in the brain at microscopic scales. Imaging is therefore an enabling tool in neuroscience.
The new imaging and virtual reconstruction technology developed by Johann Danzl’s group, at the Institute of Science and Technology Austria (ISTA), is a big leap in imaging brain activity and is aptly named LIONESS—Live Information Optimized Nanoscopy Enabling Saturated Segmentation. Their work has been published in Nature Methods.
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