Researchers at the University of California at Los Angeles have analyzed RNA editing in postmortem brains of four schizophrenia cohorts and uncovered a significant and reproducible trend of hypo-editing in patients of European descent.
The paper “Widespread RNA hypo-editing in schizophrenia and its relevance to mitochondrial function,” published in Science Advances, details the research team’s efforts to isolate functionally impacting RNA editing sites to understand how dysregulated editing contributes to various disorders.
In the data analysis, researchers identified 26,841 unique differential editing sites. They observed a significant trend of lower than expected amounts of RNA editing in the schizophrenia groups, which was reproduced in three of the four cohorts of European individuals.
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