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Dec 1, 2022

CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors

Posted by in category: futurism

Van Heurck et al. identify CROCCP2, a hominid-specific gene duplicate, as a human-specific modifier of neurogenesis in the developing cerebral cortex. They find that CROCCP2 is necessary and sufficient to enhance human cortical progenitor amplification and acts by decreasing primary cilia dynamics and enhancing the mTOR pathway.

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