Nov 30, 2022

Biosynthesis and Extracellular Concentrations of N, N-dimethyltryptamine (DMT) in Mammalian Brain

Posted by in category: neuroscience

Year 2019 Dmt actually produced naturally in the human brain scientists are now believing it could be the spirit molecule of the human being which is also found in mice.

N, N-dimethyltryptamine (DMT), a psychedelic compound identified endogenously in mammals, is biosynthesized by aromatic-L-amino acid decarboxylase (AADC) and indolethylamine-N-methyltransferase (INMT). Whether DMT is biosynthesized in the mammalian brain is unknown. We investigated brain expression of INMT transcript in rats and humans, co-expression of INMT and AADC mRNA in rat brain and periphery, and brain concentrations of DMT in rats. INMT transcripts were identified in the cerebral cortex, pineal gland, and choroid plexus of both rats and humans via in situ hybridization. Notably, INMT mRNA was colocalized with AADC transcript in rat brain tissues, in contrast to rat peripheral tissues where there existed little overlapping expression of INMT with AADC transcripts.

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