Apr 16, 2022

Key Signaling Pathway in Immune Cells Could Be New Alzheimer’s Target

Posted by in categories: biotech/medical, neuroscience

Summary: Tau-tangles trigger the inflammatory activation of microglia via the NF-κB pathway. Inhibiting the microglia NF-κB signaling pulled the immune cells out of their inflammatory state and reversed learning and memory problems in tau-based Alzheimer’s mouse models.

Source: Weill Cornell Medicine.

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer’s and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.

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