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Jan 19, 2022

Cellular support network boosts the regeneration of injured nerves

Posted by in category: biotech/medical

𝐍𝐞𝐰 𝐀𝐭𝐥𝐚𝐬:

The Neuro-Network.

𝐂𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐬𝐮𝐩𝐩𝐨𝐫𝐭 𝐧𝐞𝐭𝐰𝐨𝐫𝐤 𝐛𝐨𝐨𝐬𝐭𝐬 𝐭𝐡𝐞 𝐫𝐞𝐠𝐞𝐧𝐞𝐫𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐢𝐧𝐣𝐮𝐫𝐞𝐝 𝐧𝐞𝐫𝐯𝐞𝐬

𝘼𝙛𝙩𝙚𝙧 𝙖𝙣 𝙞𝙣𝙟𝙪𝙧𝙮, 𝙣𝙚𝙧𝙫𝙚𝙨 𝙤𝙛𝙩𝙚𝙣 𝙨𝙩𝙧𝙪𝙜𝙜𝙡𝙚 𝙩𝙤 𝙧𝙚𝙜𝙧𝙤𝙬 𝙘𝙤𝙢𝙥𝙡𝙚𝙩𝙚𝙡𝙮, 𝙡𝙚𝙖𝙫𝙞𝙣𝙜 𝙥𝙖𝙩𝙞𝙚𝙣𝙩𝙨 𝙬𝙞𝙩𝙝 𝙧𝙚𝙙𝙪𝙘𝙚𝙙 𝙢𝙤… See more.


After an injury, nerves often struggle to regrow completely, leaving patients with reduced mobility and sensation. In tests on rats, Irish researchers have now demonstrated a way to improve nerve repair using proteins from the supporting network around cells.

Peripheral nerves have some capacity for regeneration after an injury, but they often need help. For major damage, sections can be surgically replaced with nerves taken from other parts of the patient’s body, but that obviously creates injuries elsewhere. Implants called nerve guidance conduits (NGCs) are often used, which, as the name suggests, help direct nerves to regenerate along specific paths.

For the new study, researchers from the Royal College of Surgeons in Ireland investigated a new way to improve NGCs. The team loaded the nerve guidance conduits with a finely tuned mix of proteins from the extracellular matrix (ECM), a scaffold structure that provides support and supplies nutrients for cells in the body. The idea was to mimic the body’s usual nerve repair processes to reduce the need for drugs or stem cells.

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