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Aug 18, 2021

Histamine and Inflammation Could Be Key Players in Depression

Posted by in category: neuroscience

What is causing chronic inflammation?


Summary: A new study adds to the growing body of research linking inflammation to depression. Researchers found the molecule histamine directly inhibits the release of serotonin in the brain by attaching to inhibitory receptors on serotonin neurons in mice.

Source: Imperial College London

The findings, from researchers at Imperial College London and University of South Carolina, add to mounting evidence that inflammation, and the accompanying release of the molecule histamine, affects a key molecule responsible for mood in the brain – serotonin.

If replicated in humans, the findings – which identify histamine as a ‘new molecule of interest’ in depression – could open new avenues for treating depression, which is the most common mental health problem worldwide.

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