Jul 3, 2021

Scientists publish a how-to guide for creating mouse-human chimeric embryos

Posted by in categories: biotech/medical, innovation

A year after University at Buffalo scientists demonstrated that it was possible to produce millions of mature human cells in a mouse embryo, they have published a detailed description of the method so that other laboratories can do it, too.

The ability to produce millions of mature human in a living organism, called a chimera, which contains the cells of two species, is critical if the ultimate promise of to treat or cure is to be realized. But to produce those mature cells, human primed stem cells must be converted back into an earlier, less developed naive state so that the can co-develop with the inner cell mass in a blastocyst.

The protocol outlining how to do that has now been published in Nature Protocols by the UB scientists. They were invited to publish it because of the significant interest generated by the team’s initial publication describing their breakthrough last May.

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