Jul 25, 2020

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

Posted by in category: chemistry

During collective cell migration, directional information is transmitted from a leading edge to the follower cells as a form of ERK activation waves. Hino et al. demonstrate that a mechanochemical feedback loop coupling cell deformation and ERK activation enables sustained propagation of the directional information over a tissue-scale expanse.

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