Feb 28, 2020

CRISPR Edited Immune Cells Successful in First U.S. Clinical Trial

Posted by in categories: bioengineering, biotech/medical

Great news.

The successful delivery of CRISPR/Cas9 modified immune cells to cancer patients represents the first U.S. clinical trial to test the gene editing approach in humans.

Researchers from the Abramson Cancer Center of the University of Pennsylvania have published data suggesting that immune cells modified using the gene editing tool CRISPR/Cas9 are able to survive and function for months following delivery to cancer patients [1].

The research team demonstrated that T cells taken from patients and modified ex vivo (outside the body) can be safely returned to the patient and continue to survive and fight cancer. The cells were successfully edited in three ways: by deleting the TRAC, TRBC, and PDCD1 genes. In addition to these edits, a cancer-specific T cell receptor was inserted to target the NY-ESO-1 antigen to help improve the T cells’ ability to detect tumors.

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