Researchers at the University of Dundee have made a discovery they believe has the potential to put the brakes on the ‘runaway train’ that is Parkinson’s disease.
The team, based at the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) in the School of Life Sciences, have discovered a new enzyme that inhibits the LRRK2 pathway. Mutations of the LRRK2 gene are the most common cause of genetic Parkinson’s.
Enzymes are molecular machines that regulate the biological processes required to maintain healthy functioning life. They can also be targeted by drugs to increase or decrease the level of certain activity –in this instance the LRRK2 pathway.
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