Jan 10, 2018

AI can warn researchers where CRISPR might make a mistake

Posted by in categories: biotech/medical, robotics/AI

Microsoft has built an AI tool that predicts the accuracy of CRISPR so that researchers can avoid making incorrect edits of DNA.

Missing the target: CRISPR uses two components: a cutting protein and a guide RNA that directs it to the part of a genome you want to cut. The guide RNA is about 20 letters long. Problem is, multiple sites in a genome can have the same series of letters, so CRISPR could snip the wrong section—known as an “off target” effect.

Why that matters: Off-target effects are one of the biggest safety concerns with CRISPR. Making incorrect cuts in a genome could, say, switch on a cancer-causing gene.

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