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2-minute pitch for my startup Cathedral Therapeutics (co-founded with David Curiel)! If you’re interested, please feel free to reach out.


Cathedral’s novel technology protects adeno-associated virus (AAV) gene therapies from the immune system so that all patients can access the life-changing cures they need. We encapsulate AAVs inside of hollow organelles found in human cells called protein vaults to make vaultAAV complexes. This approach shields the encapsulated AAVs from antibodies so that they can enter cells and deliver beneficial DNA. https://www.cathedraltherapeutics.com/

Neptune and Uranus are the seventh and eighth planets from the sun, and as such share a lot of the same characteristics. Though they are different colors (Neptune is bluer than Uranus’ cyan hue) and have different numbers of rings and moons, both planets are ice giants that are similar sizes at just over 30,000 miles (50,000 kilometers) wide each. They also weigh about the same, with Neptune coming in at 1.024 × 1026 kg (about 17 times the mass of Earth) and Uranus weighing 8.682 × 1025 kg (about 14 times the mass of Earth). What’s more, both planets have upper atmospheres made up of mostly hydrogen, helium, and methane. Put simply, then, the characteristics of Neptune and those of Uranus are very similar despite their different colors.

Now, it seems the two worlds could have yet another thing in common, and this one is particularly intriguing when compared with Earth. Neptune and Uranus might be home to some incredibly deep oceans that make our own look like puddles.

Earth’s own oceans are already mysterious enough. They cover roughly 70% of the planet’s surface, yet only a small portion of our ocean has been explored, with the Nippon Foundation-Gebco stating that as of June 2024, just 26.1% of the entire seafloor had been mapped. The deepest trench in the ocean, known as the Challenger Deep, sits beneath the western Pacific Ocean, southwest of the U.S. territorial island of Guam, and is roughly 35,876 feet deep. Just what life is like at such depths remains somewhat of a mystery, with the deep ocean already proving to be home to prehistoric sea animals that are, frankly, nothing short of nightmare fuel. But the deepest ocean trenches on Earth are absolutely nothing compared to the depths of the oceans that might well exist on Neptune and Uranus.

Buildings cost a lot these days. But when concrete buildings are being constructed, there’s another material that can make them less expensive: mud.

MIT researchers have developed a method to use lightly treated mud, including soil from a building site, as the “formwork” molds into which concrete is poured. The technique deploys 3D printing and can replace the more costly method of building elaborate wood formworks for concrete construction.

“What we’ve demonstrated is that we can essentially take the ground we’re standing on, or waste soil from a construction site, and transform it into accurate, highly complex, and flexible formwork for customized concrete structures,” says Sandy Curth, a PhD student in MIT’s Department of Architecture who has helped spearhead the project.

Engineers are renowned clock-problem solvers. They’re also notorious for treating every problem like a clock. Increasing specialization and cultural expectations play a role in this tendency. But so do engineers themselves, who are typically the ones who get to frame the problems they’re trying to solve in the first place.

In his latest book, Wicked Problems, Guru Madhavan argues that the growing number of cloudy problems in our world demands a broader, more civic-minded approach to engineering. “Wickedness” is Madhavan’s way of characterizing what he calls “the cloudiest of problems.” It’s a nod to a now-famous coinage by Horst Rittel and Melvin Webber, professors at the University of California, Berkeley, who used the term “wicked” to describe complex social problems that resisted the rote scientific and engineering-based (i.e., clock-like) approaches that were invading their fields of design and urban planning back in the 1970s.

Madhavan, who’s the senior director of programs at the National Academy of Engineering, is no stranger to wicked problems himself. He’s tackled such daunting examples as trying to make prescription drugs more affordable in the US and prioritizing development of new vaccines. But the book isn’t about his own work. Instead, Wicked Problems weaves together the story of a largely forgotten aviation engineer and inventor, Edwin A. Link, with case studies of man-made and natural disasters that Madhavan uses to explain how wicked problems take shape in society and how they might be tamed.

Earth is 4.5 billion years old… modern humans are only 300,000 years old. The history of our species on this planet is incredible, but there are theories that humankind is actually much more spread out across the universe!

This is Unveiled, giving you incredible answers to extraordinary questions!

Find more mind-bending videos here:
What If Humanity Was a Type II Civilization? — • What If Humanity Was A Type II Civili…
What If Humanity Was a Type IV Civilization? — • What If Humanity Was A Type IV Civili…

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“Just like tuning forks of different material will have different pure tones, remnants described by different equations of state will ring down at different frequencies,” Rezzolla said in a statement. “The detection of this signal thus has the potential to reveal what neutron stars are made of.”

Gravitational waves were first suggested by Albert Einstein in this 1915 theory of gravity, known as general relativity.

Researchers have created a new AI algorithm called Torque Clustering, which greatly enhances an AI system’s ability to learn and identify patterns in data on its own, without human input.

Researchers have developed a new AI algorithm, Torque Clustering, which more closely mimics natural intelligence than existing methods. This advanced approach enhances AI’s ability to learn and identify patterns in data independently, without human intervention.

Torque Clustering is designed to efficiently analyze large datasets across various fields, including biology, chemistry, astronomy, psychology, finance, and medicine. By uncovering hidden patterns, it can provide valuable insights, such as detecting disease trends, identifying fraudulent activities, and understanding human behavior.

Elon Musk has announced that xAI will launch its large language model (LLM), Grok 3, on Monday at 8:30PM Pacific Time (that’s 10:00AM India time). The billionaire also promised that Grok 3 will be the smartest AI in the world.

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Confirming the launch of Grok 3 on X (formerly Twitter), Musk wrote, “Grok 3 release with live demo on Monday night at 8pm PT. Smartest AI on Earth.”