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Oct 2, 2023

Cell biologists identify new organelle present in mammalian cells made of rings of DNA

Posted by in categories: biotech/medical, life extension

Researchers at ETH Zurich recently identified a previously unknown compartment in mammalian cells. They have named it the exclusome. It is made up of DNA rings known as plasmids. The researchers have published details of their discovery in the journal Molecular Biology of the Cell.

The new compartment is in the cell plasma; it is previously uncharacterized in the literature. It is exceptional because eukaryotic cells (cells with nuclei) usually keep most of their DNA in the , where it is organized into chromosomes.

Some of the plasmids that end up in the exclusome originate from outside the cell, while others—known as telomeric rings—come from the capped ends of chromosomes, the telomeres. Particularly in certain , the ones from the telomeres are regularly pinched off and joined together to form rings. However, these don’t contain the blueprints for proteins.

Oct 2, 2023

Team elucidates mechanism for maximizing therapeutic effects of magnetic nanotherapeutics for cancer

Posted by in categories: biotech/medical, nanotechnology, robotics/AI

A team led by Professor Choi Hong-Soo in the Department of Robotics and Mechatronics Engineering at DGIST has discovered a method to enhance the penetration of magnetic nanoparticles into cancer cells and their magnetic hyperthermia effects through research on chain disassembly and magnetic propulsion mechanisms using a rotational magnetic field.

Published in the journal ACS Nano, their study focused on the delivery of magnetic therapeutic agents using magnetic fields, an area receiving attention in the field of cancer treatment. It is expected to contribute significantly by improving drug delivery efficiency and therapeutic effects in targeted cancer treatments.

Recently, the development of targeted therapeutics that selectively treat has been gaining attention in the field of cancer treatment. Among them, research on magnetic carriers that target cancer cells using magnetic fields is underway. However, a problem arises when magnetic nanoparticles are exposed to a uniform magnetic field with a general form; they form long chains in the direction of the magnetic field, making penetration into cancer cells or tumors difficult and reducing the therapeutic efficacy.

Oct 2, 2023

Targeting A $2 Dose AGING REVERSAL Therapy For Everyone

Posted by in categories: biotech/medical, genetics, life extension

George Church at his most optimistic. June 1, 2022.

Dr George Church talks about combination therapies for age reversal, recently published papers from his lab and expresses his wish on developing inexpensive gene therapies like vaccine that can be equitably distributed to human.

Continue reading “Targeting A $2 Dose AGING REVERSAL Therapy For Everyone” »

Oct 2, 2023

Cholesterol Esters: Underrated Metabolites That Are Associated With Youth And Survival

Posted by in categories: biotech/medical, genetics, health

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Oct 2, 2023

SpaceX Ramps Up Starlink Internet Speeds With Thousands of Space Lasers

Posted by in categories: internet, satellites

Starlink is upgrading its satellite constellation to rev up its internet service. The company launched 8,000 upgraded space lasers capable of transmitting data at speeds up to 100 Gbps.

On September 26, Starlink posted a look at the improved V2 Mini satellites, which will enhance the constellation’s speed, reliability, and reach.

“Our next generation Starlink optical space lasers (pew pew!) were launched to orbit on Monday,” Starlink tweeted on X (formerly Twitter).

Oct 2, 2023

World-first Dutch program will use ride-share cars as a grid battery

Posted by in categories: energy, sustainability, transportation

Renewable energy grids need lots of energy storage – and EVs plugged into charging stations represent a huge, city-wide battery just waiting to help out. The Dutch city of Utrecht is about to pioneer a clever way to kickstart two-way charging.

The idea has been done plenty at the domestic level – where devices like Toyota’s V2H (vehicle-to-home) charging system can turn an electric car into a high-powered backup power supply capable of running your whole home for days at a time.

And people have been talking about it on a broader, city-wide scale since the dawn of the EV revolution; the same high power density batteries that makes EVs so quick to accelerate make them perfect for quickly sending power back into the grid to smooth out demand spikes.

Oct 2, 2023

Generative AI will far surpass what ChatGPT can do. Here’s everything on how the tech advances

Posted by in category: robotics/AI

Scholars at Carnegie Mellon University recently offered what they call a “High-Modality Multimodal Transformer,” which combines not just text, image, video, and speech but also database table information and time series data. Lead author Paul Pu Liang and colleagues report that they observed “a crucial scaling behavior” of the 10-mode neural network. “Performance continues to improve with each modality added, and it transfers to entirely new modalities and tasks.”

Scholars Yiyuan Zhang and colleagues at the Multimedia Lab of The Chinese University of Hong Kong boosted the number of modalities to a dozen in their Meta-Transformer. Its point clouds model 3D vision, while its hyper-spectral sensing data represents electromagnetic energy reflected back from the ground to fly-over images of landscapes.

The immediate payoff of multi-modality will simply be to enrich the output of a thing such as ChatGPT in ways that go far beyond the “demo” mode. A children’s storybook, a book with text passages combined with pictures illustrating the text, is one immediate example. By combining the language and image attributes, the kinds of pictures created by the diffusion process can be more subtly controlled from picture to picture.

Oct 2, 2023

Tower of Power Charges EVs, No Grid Required

Posted by in categories: food, sustainability

Solar-and wind-based EV charger originally designed for off-grid farms.

Oct 2, 2023

Psychedelics plus psychotherapy can trigger rapid changes in the brain − new research at the level of neurons is untangling how

Posted by in categories: biotech/medical, neuroscience

The human brain can change – but usually only slowly and with great effort, such as when learning a new sport or foreign language, or recovering from a stroke. Learning new skills correlates with changes in the brain, as evidenced by neuroscience research with animals and functional brain scans in people. Presumably, if you master Calculus 1, something is now different in your brain. Furthermore, motor neurons in the brain expand and contract depending on how often they are exercised – a neuronal reflection of “use it or lose it.”

People may wish their brains could change faster – not just when learning new skills, but also when overcoming problems like anxiety, depression and addictions.

… More

Continue reading “Psychedelics plus psychotherapy can trigger rapid changes in the brain − new research at the level of neurons is untangling how” »

Oct 2, 2023

Spotify spotted developing AI-generated playlists created with prompts

Posted by in category: robotics/AI

Following the successful launch of Spotify’s AI-powered DJ feature and, more recently, added support for AI-translated podcasts, Spotify now appears to be developing another means of using AI in its app: AI-powered playlists. References discovered in the app’s code indicate the company may be developing generative AI playlists users could create using prompts.

The additions were uncovered by tech veteran-turned-investor Chris Messina, who posted screenshots of code in Spotify’s app that refer to “AI playlists” and “playlists based on your prompts.” He theorized that creating these may be an option within the Blend genre, where the tastes of different users are mixed to create a playlist with songs that everyone likes.

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