Photographer Stephen Voss has been working on a project about data centers and recently travelled to Abilene, Texas to document the first data center built as part of the Stargate Project. When completed, it will be the largest data center in the world. Here’s a short drone video he took of the project:
“The place was mesmerizing and deeply unsettling,” Voss told me over email. “When finished, it’ll have the power demands of a mid-sized city and is on a piece of land that’s the size of Central Park.”
In advance of a star called T Coronae Borealis (T CrB) or the “Blaze Star” exploding in a very rare event, NASA is advising sky-watchers to get to know its constellation.
Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numerous regulatory proteins. Dysregulations of NAD metabolism are widely regarded as detrimental to health, with NAD depletion commonly implicated in aging. However, the extent to which cellular NAD concentration can decline without adverse consequences remains unclear. To investigate this, we generated a mouse model in which nicotinamide phosphoribosyltransferase (NAMPT)-mediated NAD+ biosynthesis was disrupted in adult skeletal muscle. The intervention resulted in an 85% reduction in muscle NAD+ abundance while maintaining tissue integrity and functionality, as demonstrated by preserved muscle morphology, contractility, and exercise tolerance. This absence of functional impairments was further supported by intact mitochondrial respiratory capacity and unaltered muscle transcriptomic and proteomic profiles. Furthermore, lifelong NAD depletion did not accelerate muscle aging or impair whole-body metabolism. Collectively, these findings suggest that NAD depletion does not contribute to age-related decline in skeletal muscle function.
#Aging #Longevity aging and longevity.
NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, and mitochondrial function remain unaffected, suggesting that NAD depletion does not drive age-related muscle decline.
Featuring the Electro-Mechanical Brake and by-wire technology on the rear brakes, the project will also include ZF’s Integrated Brake Control and traditional front calipers, creating a ‘hybrid’ braking system of by-wire and hydraulics that offers increased flexibility to the manufacturer. The agreement will also provide significant steering technology with ZF’s Electric Recirculating Ball Steering Gear. This cutting-edge braking technology combined with traditional braking systems and innovative steering tools further solidifies ZF’s position as the industry leader in providing complete chassis solutions to its customers while providing a major customer win.
“We are all proud to see ZF’s technology leadership in the Chassis segment providing tangible value for our customers. Our goal when combining our steering, braking, dampers and actuators as well as corresponding software businesses into a single division was to create the world’s most comprehensive Chassis Solutions product and system offering,” said Peter Holdmann, Board of Management member at ZF and head of Division Chassis Solutions. “This combined center of expertise allows us to offer comprehensive solutions that integrate advanced engineering, innovative design, and cutting-edge technology to deliver unparalleled performance and safety.”
The road to the software-defined vehicle With the Electro-Mechanical Brake (EMB) as a key component of the brake-by-wire technology, ZF lays the foundation for the software-defined vehicle that will lead to new functions and features, many that emphasize safety as much as driving comfort. One such feature being explored with by-wire technology is the ability for the vehicle to autonomously brake and steer in a crash situation.
ZF’s Electro-Mechanical Brake provides premium performance for automatic emergency braking, full energy recuperation and redundant fallback options up to full automated driving for passenger car and light truck segments.
The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by Radboud University Medical Center shows how this process works. Lactate, a product of scaled-up energy production, appears to play a leading role.
The immune system protects people in two ways. Innate immunity protects us from birth against many bacteria and viruses, while adaptive immunity builds protection against individual pathogens after a prior infection. The adaptive immune system is aided by vaccines that protect us against new pathogens without having to go through an infection. In this way, vaccines contribute greatly to our health.
Results of a large, global clinical trial spanning five continents with over 1,700 patients with bronchiectasis, published this April in the New England Journal of Medicine, demonstrated benefits of an investigational, once-a-day pill called brensocatib as a therapy for the chronic lung condition.
The clinical trial findings are important, as there are currently no FDA-approved medications for bronchiectasis, a chronic condition with persistent lung airway inflammation and infection. Bronchiectasis can often stem from various injuries to the airways causing the ‘bronchial’ tubes leading to the lungs to become permanently enlarged, and more prone to infection and chronic inflammation.
In this Review, the authors discuss mass spectrometry (MS) imaging and spatially resolved MS approaches that are being employed in nephrology applications. They also highlight emerging MS methods and applications, as well as the integration of MS data with data from other omics approaches.
