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Quantum ground states: Scalable counterdiabatic driving technique enables reliable and rapid preparation

Quantum ground states are the states at which quantum systems have the minimum possible energy. Quantum computers are increasingly being used to analyze the ground states of interesting systems, which could in turn inform the design of new materials, chemical compounds, pharmaceutical drugs and other valuable goods.

The reliable preparation of quantum ground states has been a long-standing goal within the physics research community. One quantum computing method to prepare ground states and other desired states is known as adiabatic state preparation.

This is a process that starts from an initial Hamiltonian, a mathematical operator that encodes a system’s total energy and for which the ground state is known, gradually changing it to reach a final Hamiltonian, which encodes the final ground state.

The Waist-To-Hip RatioModifies LP(a)-Associated CVD Risk

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Simple amino acid supplement greatly reduces Alzheimer’s damage

Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and improved behavior. Its strong safety record and low cost make it a promising repurposing candidate. The findings hint at a surprisingly simple path toward more accessible AD therapies.

Astrocytes clear amyloid plaques and preserve cognitive function in Alzheimer’s mouse models

Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer’s disease and preserves cognitive function. The mechanism involves recruiting brain cells known as astrocytes, star-shaped cells in the brain, to remove the toxic amyloid plaques that build up in many Alzheimer’s disease brains.

Increasing the production of Sox9, a key protein that regulates functions during aging, triggered the astrocytes’ ability to remove . The study, published in Nature Neuroscience, suggests a potential astrocyte-based therapeutic approach to ameliorate cognitive decline in neurodegenerative disease.

“Astrocytes perform diverse tasks that are essential for normal brain function, including facilitating brain communications and memory storage. As the brain ages, astrocytes show profound functional alterations; however, the role these alterations play in aging and neurodegeneration is not yet understood,” said first author Dr. Dong-Joo Choi, who was at the Center for Cell and Gene Therapy and the Department of Neurosurgery at Baylor while he was working on this project. Choi currently is an assistant professor at the Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine at the University of Texas Health Science Center at Houston.

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