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A new study from Columbia University Mailman School of Public Health and the Columbia Butler Aging Center suggests that risk factors and biomarkers related to Alzheimer’s disease are associated with cognition much earlier in life than previously recognized. The study highlights significant associations between cognition and Alzheimer’s disease risk factors as young as ages 24 to 44 and underscores the importance of early prevention.

This is the first study to systematically examine Alzheimer’s disease risk factors, including biomarkers related to in a large group of generally healthy middle-aged individuals in the U.S. The findings are published in The Lancet-Regional Health Americas.

“Previously, research on Alzheimer’s disease risk factors has focused on individuals aged 50 and older,” said Allison Aiello, Ph.D., James S. Jackson Healthy Longevity Professor of Epidemiology in the Butler Aging Center and Columbia Mailman School. “The potential impact of our findings is substantial, offering clinicians and health researchers a clearer understanding of the early emergence of Alzheimer’s disease risk factors and their association with cognition before middle age.

Despite advances in wastewater treatment, tiny plastic particles called microplastics are still slipping through, posing potential health and environmental hazards, according to new research from The University of Texas at Arlington.

Because plastic is inexpensive to produce yet lightweight and sturdy, manufacturers have found it ideal for use in nearly every consumer good, from food and beverage packaging to clothing and beauty products. The downside is that when a plastic item reaches the end of its useful life, it never truly disappears. Instead, it breaks down into smaller and smaller pieces called microplastics—particles five millimeters or less, about the width of a pencil eraser—that end up in our soil and water.

“What our systematic literature review found is that while most facilities significantly reduce microplastics loads, complete removal remains unattainable with current technologies,” said Un-Jung Kim, assistant professor of Earth and environmental sciences at UT Arlington and senior author of the study published in Science of the Total Environment.

There are a seemingly endless number of quantum states that describe quantum matter and the strange phenomena that emerge when large numbers of electrons interact. For decades, many of these states have been theoretical: mathematical and computational predictions potentially hiding among real-life materials—a zoo, as many scientists are coming to refer to it, with new “species” just waiting to be discovered and described.

In a new study published on April 3 in Nature, researchers added over a dozen states to the growing quantum zoo.

“Some of these states have never been seen before,” said lead author Xiaoyang Zhu, Howard Family Professor of Nanoscience at Columbia. “And we didn’t expect to see so many either.”

Superradiant Smith-Purcell radiation (S-SPR) is a kind of free electron radiation with a train of free electron bunches passing over a periodic grating. In theory, the ultra-narrow spectral linewidth of S-SPR could be realized, which would be greatly beneficial to various applications such as imaging, sensing and communication.

However, in the free electron accelerators, customized setups and orotrons, the instability of electron , coulomb effect and the finite number of electron bunches worsened the radiation linewidth, and the large size of equipment limits the application scenarios.

In a new paper published in eLight, a team of scientists, led by Professor Fang Liu and Yidong Huang from the Department of Electronic Engineering, Tsinghua University, China, have developed the first compact S-SPR device with ultra-narrow and continuously tunable spectral linewidth.

In nature and technology, crystallization plays a pivotal role, from forming snowflakes and pharmaceuticals to creating advanced batteries and desalination membranes. Despite its importance, crystallization at the nanoscale is poorly understood, mainly because observing the process directly at this scale is exceptionally challenging. My research overcame this hurdle by employing state-of-the-art computational methods, allowing them to visualize atomic interactions in unprecedented detail.

Published in Chemical Science, my research has uncovered new details about how salt crystals form in tiny nanometer-sized spaces, which could pave the way for and improved electrochemical technologies.

This research used sophisticated enhanced by cutting-edge machine learning techniques to study how (NaCl), common table salt, crystallizes when confined between two graphene sheets separated by just a few billionths of a meter. These , known as nano-confinement, drastically alter how molecules behave compared to bulk, everyday conditions.

A massive, multi-year project led by over 150 scientists has produced the most detailed map yet of how visual information travels through the brain – revealing more than 500 million connections in a speck of mouse brain tissue.

Using glowing neurons, high-powered electron microscopes, and deep learning, researchers captured both the physical wiring and real-time electrical activity of over 200,000 brain cells. The resulting 1.6-petabyte dataset is not just a technological marvel – it brings us closer to answering age-old questions about how our brains turn light into vision and how brain disorders might arise when this system breaks.

Unraveling the Brain’s Visual Code.

Artificial intelligence models have immense potential for diagnosing myopia, assessing its risk factors, and predicting its outcomes. Myopia, or nearsightedness, currently affects over two billion people worldwide. When left uncorrected, it can significantly impair vision, disrupting education, e

Vision is one of the most important human senses, yet more than 300 million people around the world are at risk of losing it due to various retinal diseases. Although recent treatments have helped slow the progression of these conditions, no effective therapy has been able to restore vision that has already been lost, until now. Researchers at KAIST have developed a new drug that successfully restores vision.

On March 30, KAIST announced that a research team headed by Professor Jin Woo Kim from the Department of Biological Sciences has created a treatment that regenerates retinal nerves to restore vision.

Light can tie knots—literally. Engineers at Duke University have managed to manipulate laser beams to form intricate 3D patterns called optical knots, using custom-designed optics.

These twisted beams could one day carry information or measure air turbulence, but researchers discovered that real-world conditions like turbulent air can distort them more than expected. To combat this, they modified the knot’s shape to make it more resilient, opening new paths for using light in surprising ways.

Light beams can tie knots too

Scientists have found a clever way to double the efficiency of thermoelectric materials — those that convert heat into electricity — by mixing two substances with contrasting mechanical properties but similar electronic traits.

The result is a hybrid that blocks heat at microscopic interfaces while allowing electricity to flow freely, bringing us closer to cheaper, more stable alternatives to today’s gold-standard materials used in the Internet of Things and beyond.

Boosting thermoelectrics for the internet of things.