Correlations between pain phenotypes and psychiatric traits such as depression and the personality trait of neuroticism are not fully understood. In this study, we estimated the genetic correlations of eight pain phenotypes (defined by the UK Biobank, n = 151,922–226,683) with depressive symptoms, major depressive disorders and neuroticism using the cross-trait linkage disequilibrium score regression (LDSC) method integrated in the LD Hub. We also used the LDSC software to calculate the genetic correlations among pain phenotypes. All pain phenotypes, except hip pain and knee pain, had significant and positive genetic correlations with depressive symptoms, major depressive disorders and neuroticism. All pain phenotypes were heritable, with pain all over the body showing the highest heritability (h2 = 0.31, standard error = 0.072). Many pain phenotypes had positive and significant genetic correlations with each other indicating shared genetic mechanisms. Our results suggest that pain, neuroticism and depression share partially overlapping genetic risk factors.
Our universe may be riddled with defects in space-time known as cosmic strings. Though we don’t have any evidence yet that they exist, they may still be out there, and I promise that you really don’t want to encounter one.
The atmosphere is fluid. This means it’s subject to fluid dynamics, such as circulation, currents, and, yes, gravity waves. The atmosphere is always in motion, so these phenomena happen all the time; but actually seeing them is another matter.
Well, thanks to weather satellites, now you can take a mighty gawk at atmospheric gravity waves that rippled out over Western Australia last week.
Not to be confused with gravitational waves, which are disturbances in the curvature of spacetime created by massive acceleration, gravity waves, also known as buoyancy waves, are a physical phenomenon where waves are generated in any fluid medium, such as waves at the beach, or ripples in a glass of water.
A failing pipe can be tough to spot. It may cause a puddle, produce another sign of damage, or simply burst before detection. A flooded kitchen or laundry room is messy and inconvenient, but the stakes are much, much higher in nuclear power plants—which on average contain many miles of pipeline.
As concern about aging plants escalates, Vanderbilt engineers are working on an early warning system. They are using polymer coatings on the inside of the pipe and 3D-printed polymer devices infused with nanoparticles as sensors to signal the changes on the outside of the pipe. And, they hope, sound.
A huge challenge is to detect the changes in the polymer film occurring inside the pipe. To create a useful and proactive technique, the team wants to use sound, or vibrometry, to identify these internal changes from outside the pipe.