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Blog – Page 91

Megha Padi & team now show pyrvinium pamoate has antitumor activity through multiple pathways in pre-clinical models:

The figure shows tumor tissue from control mice or those treated with pyrvinium.

1University of Arizona Cancer Center, Tucson, Arizona, USA.

2Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA.

3Department of Pharmacology and Toxicology, The University of Arizona R. Ken Coit College of Pharmacy, Skaggs Pharmaceutical Sciences Center, Tucson, Arizona, USA.

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A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and colleagues around the world, has discovered that the genes we are born with—known as germline genetic variants—play a powerful, underappreciated role in how cancer develops and behaves.

Published in the April 14 online issue of Cell, the study, “Precision Proteogenomics Reveals Pan-Cancer Impact of Germline Variants,” is the first to detail how millions of inherited influence the activity of thousands of proteins within tumors.

Drawing on data from more than 1,000 patients across 10 different cancer types, the research illustrates how a person’s unique genetic makeup can shape the biology of their cancer.

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A cutting-edge AI acceleration platform powered by light rather than electricity could revolutionize how AI is trained and deployed. Using photonic integrated circuits made from advanced III-V semiconductors, researchers have developed a system that vastly outperforms traditional silicon GPUs in

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A team of over 150 scientists has achieved what once seemed impossible: a complete wiring and activity map of a tiny section of a mammalian brain. This feat, part of the MICrONS Project, rivals the Human Genome Project in ambition and scope, using cutting-edge AI, microscopy, and teamwork to map

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Researchers at Imperial College London and Lund University in Sweden found that by giving heart attack patients two drugs together – statins and ezetimibe, a cholesterol-lowering drug – their risk of another heart attack, stroke or death was reduced.

“This study shows that we could save lives and reduce further heart attacks by giving patients a combination of two low-cost drugs,” said Prof Kausik Ray, of Imperial’s School of Public Health.

But at the moment patients across the world aren’t receiving these drugs together. That is causing unnecessary and avoidable heart attacks and deaths – and also places unnecessary costs on healthcare systems.

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Since most cells naturally repel DNA, delivering these nanodevices into cells requires specialized techniques, such as transfection methods and transformation protocols. Once inside, cellular factors such as salt concentration, molecular crowding, and heterogeneous environments influence strand displacement reactions. To overcome the limitations of direct delivery, researchers are also developing transcribable RNA nanodevices encoded into plasmids or chromosomes, allowing cells to express these circuits.

Toward Smart DNA Machines and Biocomputers

DNA strand displacement has been applied to the innovation of computational models. By integrating computational principles with DNA strand displacement, the structured algorithms of traditional computing can be combined with random biochemical processes and chemical reactions in biological systems, enabling biocompatible models of computation. In the future, DNA strand displacement may enable autonomously acting DNA nanomachines to precisely manipulate biological processes, leading to quantum leaps in healthcare and life science research.

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