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Jan 25, 2018

We are happy to announce Dr. Michael West as a speaker for the 2018 Undoing Aging Conference

Posted by in category: life extension

Dr. West keynoted at the very first SENS conference, back in 2003 in Cambridge, and it’s a true delight…

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Jan 25, 2018

How To Launch A Space Startup

Posted by in categories: policy, space travel

New technology, investment, and policy are helping to boost smaller companies like Rocket Lab into the stratosphere. Their founders share some advice.

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Jan 25, 2018

TIGIT as a Biomarker for T Cell Senescence and Exhaustion

Posted by in categories: biotech/medical, life extension

In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.


In a new study, researchers propose that TIGIT is a marker of T cell senescence and exhaustion in the immune system[1]. However, not only is TIGIT just a biomarker, it is also a potential therapeutic target; as the researcher team discovered, lowering levels of TIGIT resulted in the restoration of some lost function in T cell populations that were experiencing high levels of senescence and exhaustion.

Aging is associated with immune dysfunction, especially T-cell defects, which result in increased susceptibility to various diseases. Previous studies showed that T cells from aged mice express multiple inhibitory receptors, providing evidence of the relationship between T-cell exhaustion and T-cell senescence. In this study, we showed that T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT), a novel co-inhibitory receptor, was upregulated in CD8 + T cells of elderly adults. Aged TIGIT + CD8 + T cells expressed high levels of other inhibitory receptors including PD-1 and exhibited features of exhaustion such as downregulation of the key costimulatory receptor CD28, representative intrinsic transcriptional regulation, low production of cytokines, and high susceptibility to apoptosis. Importantly, their functional defects associated with aging were reversed by TIGIT knockdown.

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Jan 25, 2018

What happens when AI tries too hard to improve reality, in one photo

Posted by in category: robotics/AI

Technically speaking, Google Photos Assistant did a pretty good job.

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Jan 25, 2018

Scientists building world’s most-powerful ‘SUPER LASERS’ that can RIP holes in space

Posted by in category: space

A NEW laser is being built that is powerful enough to rip apart empty space.

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Jan 25, 2018

Noumena’s Robotic Habitats Questions The Evolution of Artificial Intelligence

Posted by in categories: habitats, mapping, robotics/AI, space

for the 2017 tallinn architecture biennale, noumena has presented its installation based on the future of robots and its adaptability with the environment. deep learning has paved the way for machines to expand beyond narrow capabilities to soon achieving human-level performance on intellectual tasks. however, as artificial intelligence — A.I. — establishes its place within humans, society will need to develop a framework for both to thrive. a new form of artificial life will emerge, finding space at the peripheries of humanity in order to not compete for human-dominated resources. A.I. will attempt to improve its operating surroundings to not just survive but be self-sustaining, forming the basis of a civilization constrained at the intersection of nature and technology.


image © tõnu tunnel.

barcelonian based practice noumena has developed a framework to build this narrative based on the cross disciplinary intersection of computational design, mechanical and electronic design, rapid prototyping interaction and mapping. nowadays, computing tools as well as rapid prototyping machines allow to have a quick practical feedback on design solutions and to iterate experimenting different possibility at the same time giving the chance to choose and custom a functional part.

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Jan 25, 2018

DARPA Wants to Build an Image Search Engine out of DNA

Posted by in category: biotech/medical

And your photos could end up in its database.

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Jan 25, 2018

Behind the simulations imagining the nuclear apocalypse

Posted by in categories: cybercrime/malcode, finance

Security experts say more of these hands-on demonstrations are needed to get an industry traditionally focused on physical protection to think more creatively about growing cyber threats. The extent to which their advice is heeded will determine how prepared nuclear facilities are for the next attack.

“Unless we start to think more creatively, more inclusively, and have cross-functional thinking going into this, we’re going to stay with a very old-fashioned [security] model which I think is potentially vulnerable,” said Roger Howsley, executive director of the World Institute for Nuclear Security (WINS).

The stakes are high for this multibillion-dollar sector: a cyberattack combined with a physical one could, in theory, lead to the release of radiation or the theft of fissile material. However remote the possibility, the nuclear industry doesn’t have the luxury of banking on probabilities. And even a minor attack on a plant’s IT systems could further erode public confidence in nuclear power. It is this cruelly small room for error that motivates some in the industry to imagine what, until fairly recently, was unimaginable.

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Jan 25, 2018

Solowheel

Posted by in category: futurism

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Jan 25, 2018

E-ink display dress

Posted by in category: futurism

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