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When gigantic stars run out of fuel they collapse under their own gravity and, in a last hurrah, send out a blast of light and matter in the most violent known explosions in the universe.

Now astronomers have discovered that these cataclysmic events, known as gamma ray bursts, release roughly twice as much energy as previously thought.

The rethink comes after an international team registered a record-breaking observation of the highest-energy radiation ever measured from gamma ray bursts.

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Promising preliminary data from one of the first human trials testing the safety and efficacy of a CRISPR gene therapy has just been revealed. Although it is too early to evaluate long-term effects, the initial reports are impressively successful for two patients with severe genetic blood diseases.

Until February of this year, when pharmaceutical companies CRISPR Therapeutics and Vertex began a large global trial into a treatment called CTX001, no human outside of China had been officially treated with a CRISPR-based gene editing therapy.

CTX001 was developed to treat two types of inherited blood disease, beta-thalassemia and sickle cell disease. Both conditions are caused by a mutation in a single gene and the treatment involves engineering a patient’s stem cells with a single genetic change designed to raise levels of fetal hemoglobin in red blood cells.

“This inverse association was robust, consistently seen across current, past, and never smokers, as well as men, women, and individuals with different backgrounds,” she adds.

Shu says the health benefits may be rooted in their prebiotic (nondigestible food that promotes growth of beneficial microorganisms in the intestines) and probiotic properties. The properties may independently or synergistically modulate gut microbiota in a beneficial way.

The research appears in JAMA Oncology. Additional coauthors are from Seoul National University and Vanderbilt.

Gamma-ray bursts appear without warning and only last a few seconds, so astronomers had to move quickly. Just 50 seconds after satellites spotted the January explosion, telescopes on Earth swiveled to catch a flood of thousands of particles of light.

“These are by far the highest-energy photons ever discovered from a gamma-ray burst,” Elisa Bernardini, a gamma-ray scientist, said in a press release.

Over 300 scientists around the world studied the results; their work was published Wednesday in the journal Nature.

Researchers from the University of Houston have reported a new device that can both efficiently capture solar energy and store it until it is needed, offering promise for applications ranging from power generation to distillation and desalination.

Unlike and , which rely on photovoltaic technology for the direct generation of electricity, the hybrid device captures heat from the sun and stores it as . It addresses some of the issues that have stalled wider-scale adoption of solar power, suggesting an avenue for using around-the-clock, despite limited sunlight hours, cloudy days and other constraints.

The work, described in a paper published Wednesday in Joule, combines molecular energy and latent heat storage to produce an integrated harvesting and for potential 24/7 operation. The researchers report a harvesting efficiency of 73% at small-scale operation and as high as 90% at large-scale operation.