Lifeboat Foundation: Safeguarding Humanity
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“Over the past 50 years [America has] gone from institutionalizing people with mental illnesses, often in subhuman conditions, [in state mental health hospitals] to incarcerating them at unprecedented and appalling rates—putting recovery out of reach for millions of Americans […] On any given day, between 300,000 and 400,000 people with mental illnesses are incarcerated in jails and prisons across the United States, and more than 500,000 people with mental illnesses are under correctional control in the community.” [1] Mental Health America (MHA) supports effective, accessible mental health treatment for all people who need it who are confined in adult or juvenile correctional facilities or under correctional control. People with mental health and substance use conditions also need an effective classification system to protect vulnerable prisoners and preserve their human rights. [2] Notwithstanding their loss of their liberty, prisoners with mental health and substance use conditions retain all other rights, and these must be zealously defended.

Background

In the past decade, America has been locking up increasing numbers of individuals with mental health conditions. [3] MHA is both concerned by and opposed to the increasing use of criminal sanctions and incarceration, replacing the state mental hospitals with much more drastic curtailment of personal liberty and preclusion of community integration and community-based treatment. [4] Prisoners with mental health conditions are especially vulnerable to the difficult and sometimes deplorable conditions that prevail in jails, prisons, and other correctional facilities. Overcrowding often contributes to inadequacy of mental health services and to ineffective classification and separation of prisoner classes. It can both increase vulnerability and exacerbate mental illnesses. For these and other reasons, MHA supports maximum reasonable diversion. [5].

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By Amy Woodyatt, CNN—Wed August 7, 2019

Thousands of tardigrades—also known as ‘water bears’ or ‘moss piglets’—were on board the Beresheet spacecraft when it crash landed on the moon in April.

(CNN)You’ve heard of men on the moon — but what about moss piglets?

Thousands of tardigrades – also known as “water bears” or “moss piglets” — were on board the Beresheet spacecraft when it crash landed on the moon in April.
The tiny creatures are incredibly hardy and can survive extremely low temperatures and harsh conditions– and The Arch Mission Foundation, which sent them into space, believes some may have survived.
Tardigrades are pudgy little animals no longer than one millimeter. They live in water or in the film of water on plants like lichen or moss, and can be found all over the world in some of the most extreme environments, from icy mountains and polar regions to the balmy equator and the depths of the sea.
Tardigrades live all over the world in some of the most extreme environments.

Tardigrades live all over the world in some of the most extreme environments.
In an attempt to create a “Noah’s ark” or a “back-up” for the Earth, non-profit organization The Arch Mission sent a lunar library — a stack of DVD-sized disks that acts as an archive of 30 million pages of information about the planet — to the moon. Along with the library, Arch Mission sent human DNA samples and a payload of tardigrades, which had been dehydrated, into space.
“We chose them because they are special. They are the toughest form of life we know of. They can survive practically any planetary cataclysm. They can survive in the vacuum of space, they can survive radiation,” Nova Spivack, co-founder of the Arch Mission Foundation, told CNN.
Bill Nye's experimental spacecraft that sails on sunlight declares mission success

Bill Nye’s experimental spacecraft that sails on sunlight declares mission success
Tardigrades have eight legs with claws at the end, a brain and central nervous system, and a sucker-like pharynx behind their mouth, which can pierce food.
The Arch Mission put the creatures into a state of “suspended animation,” where the body dries out and the metabolism slows to as little as 0.01% of its normal rate.
The Arch Mission also sent a 30 million-page library along for the ride.

The Arch Mission also sent a 30 million-page library along for the ride.
“In that state you can later rehydrate them in a laboratory and they will wake up and be alive again,” Spivack explained.
Although the animals won’t be able to reproduce or move around in their dehydrated state — if they have survived the crash — if rehydrated they could come back to life years later.
“We don’t often get a chance to land life on the moon that we decided to seize the day and send some along for the ride,” Spivack added.
Researchers hope that along with the tardigrades, the majority of the information from the lunar library survived the impact of the crash — and could be used to regenerate human life in millions of years.
“Best-case scenario is that the little library is fully intact, sitting on a nice sandy hillside on the moon for a billion years. In the distant future it might be recovered by our descendants or by a future form of intelligent life that might evolve long after we’re gone,” Spivack said.
“From the DNA and the cells that we included, you could clone us and regenerate the human race and other plants and animals,” he added.

Source: https://www.cnn.com/2019/08/07/world/water-bear-space-intl-scli-scn/index.html

IBM recently developed three artificial intelligence tools that could help medical researchers fight cancer.

Now, the company has decided to make all three tools open-source, meaning scientists will be able to use them in their research whenever they please, according to ZDNet. The tools are designed to streamline the cancer drug development process and help scientists stay on top of newly-published research — so, if they prove useful, it could mean more cancer treatments coming through the pipeline more rapidly than before.

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Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CFTR gene. The 3272–26AG and 3849+10kbCT CFTR mutations alter the correct splicing of the CFTR gene, generating new acceptor and donor splice sites respectively. Here we develop a genome editing approach to permanently correct these genetic defects, using a single crRNA and the Acidaminococcus sp. BV3L6, AsCas12a. This genetic repair strategy is highly precise, showing very strong discrimination between the wild-type and mutant sequence and a complete absence of detectable off-targets. The efficacy of this gene correction strategy is verified in intestinal organoids and airway epithelial cells derived from CF patients carrying the 3272–26AG or 3849+10kbCT mutations, showing efficient repair and complete functional recovery of the CFTR channel. These results demonstrate that allele-specific genome editing with AsCas12a can correct aberrant CFTR splicing mutations, paving the way for a permanent splicing correction in genetic diseases.

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A study on animals with autoimmune myocarditis was recently released in the journal Cell Reports [1], showing the impact of heart inflammation on the types of immune cell that are formed in the heart. This could have a significant impact on our understanding of cardiac aging.

What is myocarditis and how is it relevant to aging?

Myocarditis is a disease involving inflammation of the heart. It mainly influences people between the ages of 20 and 51 [2] [3]; however, the elderly are still affected to some degree. The disease has been known to cause serious complications, such as heart attack and heart failure.

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Genetics hold far more sway over the mouse microbiome than transient environmental exposures, researchers reported July 26 in Applied and Environmental Microbiology. The results appear to contradict previous studies in humans that have found environmental factors to be more influential than genetics, and they add to an ongoing dialogue in the microbiome research community over how much control we hold over the bacterial communities in our guts.

Hila Korach-Rechtman, a microbiologist at the Israel Institute of Technology in Haifa, set out to identify the microbes in mice that become a fixture in the gut after being introduced through the environment. “We really wanted to find these bacteria that can be transferred and remain in the host, even though they have different genetics,” she says.

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The Defense Department is looking to build tools that can quickly detect deepfakes and other manipulated media amid the growing threat of “large-scale, automated disinformation attacks.”

The Defense Advanced Research Projects Agency on Tuesday announced it would host a proposers day for an upcoming initiative focused on curbing the spread of malicious deepfakes, shockingly realistic but forged images, audio and videos generated by artificial intelligence. Under the Semantic Forensics program, or SemaFor, researchers aim to help computers use common sense and logical reasoning to detect manipulated media.

As global adversaries enhance their technological capabilities, deepfakes and other advanced disinformation tactics are becoming a top concern for the national security community. Russia already showed the potential of fake media to sway public opinion during the 2016 election, and as deepfake tools become more advanced and readily available, experts worry bad actors will use the tech to fuel increasingly powerful influence campaigns.

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