Page 8

Mar 31, 2023

Could new riboswitch make gene therapy safer?

Posted by in categories: biotech/medical, chemistry, life extension

Turning genes on and off as easily and predictably as flicking a switch could be a powerful tool in medicine and biotech. A type of technology called a riboswitch might be the key. The Okinawa Institute of Science and Technology (OIST) in Japan, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression. The technology, which was described in the Journal of the American Chemical Society, worked in mammalian cell cultures and in mice.

The ability to precisely control whether a gene is turned on or off is expected to lead to more efficient production of compounds that are made using animal cells, and make gene therapy, cell therapy, and regenerative medicine safer.

For genes to be expressed, cells make many RNA copies of a section of DNA. These RNA copies, called transcripts, are then used to make the protein. This can lead to the introduction of additional genes (either as DNA or RNA) into cells, which can then be used to make new proteins for a wide variety of applications.

Mar 31, 2023

Supply chain cyberattack with possible links to North Korea could have thousands of victims globally

Posted by in category: cybercrime/malcode

Hackers modified an enterprise communication company’s installation software in an attack that could steal credentials and other information from companies around the world, according to an analysis published Wednesday.

Researchers with cybersecurity firm SentinelOne’s SentinelLabs team traced illicit activity flagged by its detection systems back to the installation software from a company called 3CX, which according to its website provides video conferencing and online communication products to companies such as Toyota, McDonalds, Pepsi and Chevron. In total, the company says it serves some 12 million customers globally.

This sort of large-scale attack that takes advantage of a company’s supply chain — similar to how attackers leveraged a flaw within a SolarWinds product update to install backdoors inside its customers’ networks — can be difficult to defend against and could lead to devastating consequences for victims. It’s also the kind of operation that is typically associated with a nation-state hacking group.

Mar 31, 2023

Microsoft lays off entire AI ethics team while going all out on ChatGPT

Posted by in categories: ethics, robotics/AI

A new report indicates Microsoft will expand AI products, but axe the people who make them ethical.

Mar 31, 2023

Scientists use rocket to create artificial Northern Lights to better understand space weather

Posted by in category: satellites

Aurora Borealis can cause damage to satellites in severe solar storms. Scientists are experimenting to understand near-space weather better.

Mar 31, 2023

Dune — Space Folding [HD]

Posted by in categories: entertainment, space

Dune Scene Stars: Kyle MacLachlan, Francesca Annis, Jürgen Prochnow, Silvana Mangano Director: David Lynch Writers: Frank Herbert, David Lynch Producer: Raffaella De Laurentiis Music: TOTO Production: Dino De Laurentiis Company, Estudios Churubusco Azteca S.A. Distributon: Universal Pictures Released: 1984

► watch Dune

Continue reading “Dune — Space Folding [HD]” »

Mar 31, 2023

Elon Musk’s Twitter Widens Its Censorship of Modi’s Critics

Posted by in category: Elon Musk

Two months ago, Musk said he was too busy to look into his company’s role in mass censorship in India. It’s only gotten worse.

Mar 30, 2023

Allies or enemies of cancer: The dual fate of neutrophils

Posted by in category: biotech/medical

Why do cancer immunotherapies work so extraordinarily well in a minority of patients, but fail in so many others? By analyzing the role of neutrophils, immune cells whose presence usually signals treatment failure, scientists from the University of Geneva (UNIGE), from Harvard Medical School, and from Ludwig Cancer Center have discovered that there is not just one type of neutrophil, but several. Depending on certain markers on their surface, these cells can either promote the growth of tumors, or fight them and ensure the success of a treatment. By boosting the appropriate factors, neutrophils could become great agents of anti-tumor immunity and reinforce the effects of current immunotherapies. These results have been published in the journal Cell.

Immunotherapy involves activating —mainly T cells—to recognize and destroy . While this treatment is very efficient for some patients, and sometimes even exceeds expectations, it is unfortunately not the case in most cases. “The reasons for these failures remain largely unknown,” says Mikaël Pittet, full professor at the UNIGE Faculty of Medicine, holder of the ISREC chair in immuno-oncology, director of the Centre for Translational Research in Onco-Hematology and member of the Ludwig Cancer Center, who directed this work. “This is why deciphering the immune components involved is key to develop more advanced treatments and make immunotherapies a real therapeutic revolution.”

Neutrophils are the most abundant immune cells in the blood and are very useful in infections or injuries by being quickly mobilized to the affected area and releasing antimicrobial factors. In the context of cancer, however, their presence is generally bad news as they promote vascularization and tumor progression.

Mar 30, 2023

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Posted by in category: biotech/medical

In a recent study on the medRxiv preprint server, researchers identified an interleukin 6 (IL-6) dependent alternative pathway as a therapeutic strategy against coronavirus disease 2019 (COVID-19).

Study: A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19. Image Credit: MarynaOlyak/

Mar 30, 2023

Humans to attain immortality by 2029? Ex-Google scientist makes striking claim

Posted by in categories: genetics, life extension, nanotechnology, Ray Kurzweil, robotics/AI

“You won’t live forever” is a catchphrase which has often been touted and has so far remained the proven truth of life — of humans and almost every other living being on planet earth. But soon, this catchphrase may well become the truth of the past, as humanity steps forward to attain immortality.

A former Google scientist has made a prediction, which if proven right, may redefine human civilisation as we know it. Ray Kurzweil, whose over 85 per cent of 147 predictions have been proven right, has predicted that humans will become immortal by 2029.

The revelation came when the 75-year-old computer scientist dwelled upon genetics, nanotechnology, robotics and more in a YouTube video posted by channel Adagio.

Continue reading “Humans to attain immortality by 2029? Ex-Google scientist makes striking claim” »

Mar 30, 2023

Increased use of telehealth services, medications during pandemic associated with reduced risk for fatal overdose

Posted by in categories: biotech/medical, health

The expanded availability of opioid use disorder-related telehealth services and medications during the COVID-19 pandemic was associated with a lowered likelihood of fatal drug overdose among Medicare beneficiaries, according to a new study.

“The results of this study add to the growing research documenting the benefits of expanding the use of telehealth services for people with use disorder, as well as the need to improve retention and access to medication treatment for opioid use disorder,” said lead author Christopher M. Jones, PharmD, DrPH, director of the National Center for Injury Prevention and Control, Centers for Disease Control and Prevention. “The findings from this collaborative study also highlight the importance of working across agencies to identify successful strategies to address and get ahead of the constantly evolving crisis.”

Published today in JAMA Psychiatry, this study is a collaborative research effort led by researchers at the National Center for Injury Prevention and Control, a part of CDC; the Office of the Administrator and the Center for Clinical Standards and Quality, both part of the Centers for Medicare & Medicaid Services (CMS); and the National Institute on Drug Abuse, a part of the National Institutes of Health.

Page 8 of 8,894First56789101112Last