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Feb 28, 2024

Mathematicians Have Discovered the Secret Geometry of Life

Posted by in category: mathematics

From the spirals of shells to the layout of cells, a new class of shapes redefines nature’s complexity.

Feb 28, 2024

How early-stage cancer cells hide from the immune system

Posted by in categories: biotech/medical, genetics

One of the immune system’s primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells manage to evade this surveillance and develop into more advanced tumors.

A new study from MIT and Dana-Farber Cancer Institute has identified one strategy that helps these avoid immune detection. The researchers found that early in colon cancer development, cells that turn on a gene called SOX17 can become essentially invisible to the immune system.

If scientists could find a way to block SOX17 function or the pathway that it activates, this may offer a new way to treat early-stage cancers before they grow into larger tumors, the researchers say.

Feb 28, 2024

Bioinformatics approach offers a step toward personalized immunotherapy for all

Posted by in category: biotech/medical

Most cancers are thought to evade the immune system. These cancers don’t carry very many mutations, and they aren’t infiltrated by cancer-fighting immune cells. Scientists call these cancers immunologically “cold.”

Now new research suggests such cancers aren’t as “cold” as once thought. Researchers from the La Jolla Institute for Immunology (LJI), UC San Diego Moores Cancer Center, and UC San Diego, have found that patients with “cold” tumors actually do make cancer-fighting T cells.

This discovery opens the door to developing vaccines or therapies to increase T cell numbers and treat many more types of cancer than currently thought possible.

Feb 28, 2024

Sensory nerves appear to drive head and neck cancer growth

Posted by in category: biotech/medical

Researchers at the University of Colorado Anschutz Medical Campus studying interactions between nerves and tumor microenvironments have found that commonly used drugs like botox may stop or slow the progression of certain head and neck cancers.

The study, published online today in the journal Med, examined how nerves within the tumor environment impact the immune system and cancer growth.

“We have long known that the intensity of nerve interactions within the are associated with worse outcomes in head and neck squamous cell carcinoma,” said the study’s lead author Laurel Darragh, an MD/Ph. D. student focused on radiation oncology at the University of Colorado School of Medicine. “This prompted us to investigate how these nerve interactions impact the adaptive immune system and tumor growth.”

Feb 28, 2024

How your eye color might increase your risk of seasonal affective disorder

Posted by in category: biological

Eyes with lower pigment (blue or grey eyes) don’t need to absorb as much light as brown or dark eyes before this information reaches the retinal cells. This might provide light-eyed people with some resilience to SAD.

Other theories propose it happens due to an imbalance in serotonin and melatonin in the body. Serotonin makes us feel energetic, while the release of melatonin makes us feel sleepy. Since melatonin is made from serotonin, people with SAD may potentially produce too much melatonin during the winter months, leaving them feeling lethargic or down.

All these studies are inconsistent and, in some cases, contradictory. But because SAD is likely due to a combination of many biological and physiological factors working together, these different explanations for what causes SAD may well be interconnected.

Continue reading “How your eye color might increase your risk of seasonal affective disorder” »

Feb 28, 2024

Bubble Planets & Ederworlds

Posted by in category: space

Ederworlds & Bubble planets are artificial worlds held up by internal pressure, and can be several times larger than Earth.

Feb 28, 2024

Arditi Forging a New Man

Posted by in category: media & arts

To survive in the 3rd millenium we must evolve.

Feb 28, 2024

Rainbow Teaming: Open-Ended Generation of Diverse Adversarial Prompts

Posted by in category: futurism

Join the discussion on this paper page.

Feb 28, 2024

Next generation bioweapons

Posted by in categories: biotech/medical, military

Shared with Dropbox.

Feb 28, 2024

Beneficial AGI Summit & Unconference — Feb. 27/March 1, 2024

Posted by in categories: governance, robotics/AI, singularity

The “Beneficial AGI Summit & Unconference” is a new event organized by SingularityNet and TrueAGI in collaboration with others. The Millennium Project is one of the sponsors of the event and our Jerome Glenn, Executive Director and co-founder of The Millennium Project, and José Cordeiro, MP Board member and RIBER and Venezuela Nodes Chair, are members of the organizing committee of the event. The Beneficial AGI summit will take place both online and physically and c/o Hilton Panama in Panama City. The streaming is free, get your ticket.

The objective of the conference is to bring together the leading voices in AI in actions to catalyze the emergence of beneficial AGI. Key themes of the event are: Constitution & Governance Framework, Global Brain Collective, Simulation / Gaming Environments, Scenarios analysis process, Potential scenarios (from 1 to 7).

On the first two days of the BGI Summit, Feb. 27–28, top thought leaders from around the globe will engage in comprehensive, detailed discussions of a wide range of questions regarding various approaches to AGI and their ethical, economic, psychological, political, environmental and other implications. The focus will be on discussing issues, making conceptual progress, forming collaborations, and engaging in the practical actions aimed at catalyzing the emergence of beneficial AGI based on the ideas and connections set in motion by all involved.

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