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Microbial molecule that disarms inflammation discovered, offering new diabetes treatment strategy

An international research team has uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine (TMA). Published in Nature Metabolism, the study reveals that TMA, produced by gut bacteria from dietary choline, can block a key immune pathway and improve blood sugar control.

The study was led by Professor Marc-Emmanuel Dumas at Imperial College London & CNRS together with Prof. Patrice Cani (Imperial & University of Louvain, UCLouvain), Dr. Dominique Gauguier (Imperial & INSERM, Paris) and Prof. Peter Liu (University of Ottawa Heart Institute).

Lower doses of immunotherapy for skin cancer give better results, study suggests

According to a new study, lower doses of approved immunotherapy for malignant melanoma can give better results against tumors, while reducing side effects. This is reported by researchers at Karolinska Institutet in the Journal of the National Cancer Institute.

“The results are highly interesting in oncology, as we show that a lower dose of an immunotherapy drug, in addition to causing significantly fewer side effects, actually gives better results against tumors and longer survival,” says last author Hildur Helgadottir, a researcher at the Department of Oncology–Pathology at Karolinska Institutet, who led the study.

Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription

Wu, Z., Gou, K., Wang, Y. et al. Transcription factor CEBPA suppresses sepsis induced lung injury by activating SIRT4 transcription. Sci Rep 15, 42,128 (2025). https://doi.org/10.1038/s41598-025-25975-5

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New tech called ‘mind captioning’ turns thoughts and mental images into simple text

Although scientists have made progress using brain-activity scans to convert the words we think into text, translating the rich, complex images in our minds into language is still far more difficult, says lead author Tomoyasu Horikawa.

Horikawa calls this approach “mind captioning” because the system turns distinct patterns of human brain activity into short text captions.

Earlier experiments often used the label “mind reading” and focused on easier tasks, such as guessing which object someone was viewing from a short list or matching brain activity to spoken words.

After losing more than $70 billion, Mark Zuckerberg seems to have finally admitted that his biggest bet is ‘not working’

The TOI Tech Desk is a dedicated team of journalists committed to delivering the latest and most relevant news from the world of technology to readers of The Times of India. TOI Tech Desk’s news coverage spans a wide spectrum across gadget launches, gadget reviews, trends, in-depth analysis, exclusive reports and breaking stories that impact technology and the digital universe. Be it how-tos or the latest happenings in AI, cybersecurity, personal gadgets, platforms like WhatsApp, Instagram, Facebook and more; TOI Tech Desk brings the news with accuracy and authenticity.

AI Expert: We Have 2 Years Before Everything Changes! We Need To Start Protesting! — Tristan Harris

For example: “If you’re worried about immigration, you should be way more concerned about AI” — for the impact on jobs, cultural stability, and social predictability.

Ex-Google Insider and AI Expert TRISTAN HARRIS reveals how ChatGPT, China, and Elon Musk are racing to build uncontrollable AI, and warns it will blackmail humans, hack democracy, and threaten jobs…by 2027.

Tristan Harris is a former Google design ethicist and leading voice from Netflix’s The Social Dilemma. He is also co-founder of the Center for Humane Technology, where he advises policymakers, tech leaders, and the public on the risks of AI, algorithmic manipulation, and the global race toward AGI.

Please consider sharing this episode widely. Using this link to share the episode will earn you points for every referral, and you’ll unlock prizes as you earn more points: https://doac-perks.com/

He explains:

Continue reading “AI Expert: We Have 2 Years Before Everything Changes! We Need To Start Protesting! — Tristan Harris” | >

SCFFBXW11 Complex Targets Interleukin-17 Receptor A for Ubiquitin–Proteasome-Mediated Degradation

Interleukin-17 (IL-17) is a pro-inflammatory cytokine that participates in innate and adaptive immune responses and plays an important role in host defense, autoimmune diseases, tissue regeneration, metabolic regulation, and tumor progression. Post-translational modifications (PTMs) are crucial for protein function, stability, cellular localization, cellular transduction, and cell death. However, PTMs of IL-17 receptor A (IL-17RA) have not been investigated. Here, we show that human IL-17RA was targeted by F-box and WD repeat domain-containing 11 (FBXW11) for ubiquitination, followed by proteasome-mediated degradation. We used bioinformatics tools and biochemical techniques to determine that FBXW11 ubiquitinated IL-17RA through a lysine 27-linked polyubiquitin chain, targeting IL-17RA for proteasomal degradation.

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