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An interesting cautionary note on the well-intentioned effort to supply personal protective equipment (PPE), such as masks, via 3D printing. I’ll confess that I have not thought through all the implications.


“One of the hospitals calls it ‘the garage PPE,’” said Sarah Boisvert, founder of 3D-printing school Fab Lab Hub, who works with hospitals to 3D-print materials. “This is a far more complicated problem than just making Christmas ornaments for your family.”

Lovett readily admits that he is not an expert. But he and others who want to help are stymied in part by a lack of clear government regulation around simple designs.

Most citizen manufacturers are producing face shields, simple transparent visors that cover the face and project doctors from airborne pathogens. So long as they stop droplets entering the mouth, nose, and eyes, manufacturers of face shields can essentially build whatever they want, up to a point. But if they get things wrong, they “can really do damage, not to mention waste time and energy and resources,” said Boisvert. Some popular designs are too flimsy to “withstand constant daily use,” said Lin, while others “sit too close to the face,” making them unsafe for doctors who wear glasses.

Essentially, the study found that some immune systems are less capable of recognizing the infection. This diminished ability to recognize the coronavirus can make a person more susceptible to developing symptoms in general, as well as more likely to experience severe symptoms that require hospitalization.

Getting down to the scientific specifics of the findings, the study focused on the immune system genes known as human leukocyte antigen genes. These genes are highly involved in the immune system’s ability to recognize pathogens, but they come in a variety of forms and vary from person to person.

The research team, from Oregon Health & Science University and the Portland VA Research Foundation, believe that HLA gene variations may make certain people more vulnerable to the coronavirus.

The study was carried out by Professor Li Lanjuan and colleagues from Zhejiang University in Hangzhou, China and published in a non-peer reviewed paper released on website medRxiv.org on Sunday.

Li’s team analyzed the strains from 11 randomly chosen coronavirus patients from Hangzhou, where there have been 1,264 reported cases, and then tested how efficiently they could infect and kill cells.

More than 30 different mutations were detected, of which 19 were previously undiscovered.

Wingcopter and UPS Flight Forward (UPSFF) are collaborating to develop package delivery drones.

The companies will work toward earning regulatory certification for a Wingcopter unmanned aircraft to make commercial delivery flights in the United States, according to a news release. This partnership represents “a critical step toward building a diverse fleet of drones with varying capabilities to meet even more potential customer needs.”

The Wingcopter drone is capable of vertical takeoff and landing in tight spaces and transitioning to high-speed horizontal flight. Its patented tilt-rotor mechanism enables a seamless transition between the two drone modes—multicopter for hovering and fixed-wing for low-noise forward flight. The aerodynamic drone provides stability even in harsh weather conditions.

Benchmark US crude oil prices traded with negative prices for the first time in history on Monday, sending shockwaves through the global energy sector.

But what are negative prices and what do they mean for the wider industry?

US oil prices traded below zero for the first time ever, meaning producers or traders were essentially paying other market participants to take the oil off their hands.

👽 A slap to health workers.

Fyodor R. Dawn Spelling


Opening America. The President keeps teasing it in his daily propaganda, ego-stroke photo op. His sycophantic surrogates repeat the refrain on social media and in press releases. Soulless partisan television hosts pound us relentlessly with it. MAGA cult members protest mask-less and in close quarters for it.

This united offensive to quickly get Americans back to work, is all happening on days when we are losing over two thousand people a day, when we’ve eclipsed 644,000 confirmed cases, when 29,000 have died in the span of eight weeks.

And every single life that is threatened by this vicious, insidious illness—falls squarely on the shoulders of healthcare workers and first responders: doctors, nurses, EMTs, lab technicians, hospital staff, police officers, firefighters.

For weeks they have labored without sleep, without rest, without enough masks to protect themselves, without enough tests to identify the relentless flood of sick people in their midst, without enough ventilators to keep the gravely ill alive; continually stepping into harm’s way to attend to this unprecedented national emergency.

Last March, Chinese researchers announced an ingenious and potentially devastating attack against one of America’s most prized technological assets—a Tesla electric car.

The team, from the security lab of the Chinese tech giant Tencent, demonstrated several ways to fool the AI algorithms on Tesla’s car. By subtly altering the data fed to the car’s sensors, the researchers were able to bamboozle and bewilder the artificial intelligence that runs the vehicle.

National Eye Institute (NEI) researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. The findings, published online April 21 in Cell Reports, suggest that the epigenome could be targeted as a therapeutic strategy to prevent leading causes of vision loss, such as age-related macular degeneration (AMD). NEI is part of the National Institutes of Health.

“Our study elucidates the molecular changes and biological pathways linked with aging of rod photoreceptors, light-sensing cells of the retina. Future investigations can now move forward to study how we can prevent or delay vision loss in aging and hopefully reduce the risk of associated neurodegeneration” said the study’s lead investigator, Anand Swaroop, Ph.D., senior investigator and chief of the NEI Neurobiology, Neurodegeneration, and Repair Laboratory.

Each organism is born with a genome, a library of genes that control all the body’s cellular and tissue functions. Expression of those genes—when information stored in DNA is converted into instructions for making proteins or other molecules—is modulated and maintained by the organism’s epigenome. The epigenome tags the DNA code to modify gene expression in ways that can be favorable and unfavorable for survival.